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NPC1 PROTEIN
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DeCS
Descriptor
English
:
Niemann-Pick C1 Protein
Descriptor
Spanish
:
Proteína Niemann-Pick C1
Descriptor
Portuguese
:
Proteína C1 de Niemann-Pick
Synonyms
English
:
NPC1 Protein
Niemann Pick C1 Protein
Tree Number:
D12.776.157.530.594
D12.776.543.585.594
D12.776.543.750.058.250
D12.776.543.750.830.235
D12.776.624.776.633.250
Definition
English
:
A transmembrane intracellular lipid transporter that helps trafficking
lipids
, particularly
cholesterol
, from late endosome/lysosome to the ER and
plasma
membrane. It may also play a role in other cellular
cholesterol
homeostasis
and is an endosomal entry receptor for filoviruses including
EBOLAVIRUS
.
Mutations
in the NPC1 are associated with type C NIEMANN-PICK
DISEASE.
History Note
English
:
2019
Allowable Qualifiers
English
:
AD
administration & dosage
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PH
physiology
RE
radiation effects
TU
therapeutic use
UL
ultrastructure
Record Number:
57596
Unique Identifier:
D000077296
Occurrence in VHL
:
Similar:
DeCS